Raes Geert, Beschin Alain, Ghassabeh Gholamreza Hassanzadeh, De Baetselier Patrick
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Curr Opin Immunol. 2007 Aug;19(4):454-9. doi: 10.1016/j.coi.2007.05.007. Epub 2007 Jul 12.
A type 1 cytokine-dependent pro-inflammatory response inducing classically activated macrophages is crucial for parasite control during protozoan infections but can also contribute to the development of immunopathological disease symptoms. Accumulating evidence indicates that interleukins 4, 13 and 10, transforming growth factor-beta, immune complexes and apoptotic cells elicited during these infections induce alternative activation states of macrophages, affecting disease outcome by, on the one hand, promoting parasite survival and proliferation and, on the other hand, limiting collateral tissue damage because of excessive type 1 inflammation. Thus, modulation of macrophage activation may be instrumental in allowing parasite persistence and long-term host survival.
1型细胞因子依赖性促炎反应诱导经典活化的巨噬细胞，这对于原生动物感染期间的寄生虫控制至关重要，但也可能导致免疫病理疾病症状的发展。越来越多的证据表明，这些感染期间引发的白细胞介素4、13和10、转化生长因子-β、免疫复合物和凋亡细胞会诱导巨噬细胞的替代激活状态，一方面促进寄生虫的存活和增殖，另一方面限制因过度的1型炎症导致的附带组织损伤，从而影响疾病的结局。因此，调节巨噬细胞的激活可能有助于寄生虫的持续存在和宿主的长期存活。
