Yakunin Alexander F, Yee Adelinda A, Savchenko Alexei, Edwards Aled M, Arrowsmith Cheryl H
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada.
Curr Opin Chem Biol. 2004 Feb;8(1):42-8. doi: 10.1016/j.cbpa.2003.12.003.
In any newly sequenced genome, 30% to 50% of genes encode proteins with unknown molecular or cellular function. Fortunately, structural genomics is emerging as a powerful approach of functional annotation. Because of recent developments in high-throughput technologies, ongoing structural genomics projects are generating new structures at an unprecedented rate. In the past year, structural studies have identified many new structural motifs involved in enzymatic catalysis or in binding ligands or other macromolecules (DNA, RNA, protein). The efficiency by which function is deduced from structure can be further improved by the integration of structure with bioinformatics and other experimental approaches, such as screening for enzymatic activity or ligand binding.
在任何新测序的基因组中，30%至50%的基因编码的蛋白质其分子或细胞功能未知。幸运的是，结构基因组学正在成为一种强大的功能注释方法。由于高通量技术的最新进展，正在进行的结构基因组学项目正以前所未有的速度生成新结构。在过去一年中，结构研究已经确定了许多参与酶催化、结合配体或其他大分子（DNA、RNA、蛋白质）的新结构基序。通过将结构与生物信息学及其他实验方法（如筛选酶活性或配体结合）相结合，可以进一步提高从结构推断功能的效率。
