Hart Carl L, Ward Amie S, Collins Eric D, Haney Margaret, Foltin Richard W
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA.
Drug Alcohol Depend. 2004 Mar 8;73(3):279-87. doi: 10.1016/j.drugalcdep.2003.10.015.
Data from research with laboratory animals indicate that cocaine self-administration can be reduced by lambda-aminobutyric acid (GABA) agonists. Yet, the effectiveness of GABA agonists to decrease human cocaine self-administration has not been investigated under controlled laboratory conditions. The purpose of this study was to assess the effects of gabapentin, a GABA agonist, on cocaine-related behaviors, including self-administration, in human research participants under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of gabapentin (0, 600, and 1200 mg/d) maintenance on response to cocaine (0, 12, 25, and 50 mg) were investigated in seven cocaine abusers. Active cocaine significantly increased choice to self-administer cocaine, subjective-effect ratings (e.g., "Good Drug Effect"), blood pressure and heart rate (HR). Gabapentin did not reduce cocaine choice or cardiovascular measures, but it did decrease some subjective effects of cocaine (e.g., "Good Drug Effect" and "Anxious"). These data suggest that the cocaine-gabapentin combination was well-tolerated, and because some cocaine-related subjective effects were reduced by maintenance on relatively low gabapentin doses, future studies should test higher gabapentin doses.
来自对实验动物的研究数据表明，γ-氨基丁酸（GABA）激动剂可减少可卡因的自我给药行为。然而，尚未在可控的实验室条件下研究GABA激动剂减少人类可卡因自我给药行为的有效性。本研究的目的是在可控的实验室条件下，评估GABA激动剂加巴喷丁对人类研究参与者与可卡因相关行为的影响，包括自我给药行为。在这项为期48天的双盲交叉设计研究中，研究了加巴喷丁（0、600和1200毫克/天）维持剂量对7名可卡因滥用者对可卡因（0、12、25和50毫克）反应的影响。活性可卡因显著增加了自我给药可卡因的选择、主观效应评分（如“良好药物效应”）、血压和心率（HR）。加巴喷丁并未减少可卡因的选择或心血管指标，但确实降低了可卡因的一些主观效应（如“良好药物效应”和“焦虑”）。这些数据表明，可卡因-加巴喷丁组合耐受性良好，并且由于相对较低剂量的加巴喷丁维持治疗可减少一些与可卡因相关的主观效应，未来的研究应测试更高剂量的加巴喷丁。
