Must Anita, Janka Zoltán, Benedek György, Kéri Szabolcs
Department of Psychiatry, University of Szeged, Semmelweis u. 6., H-6725, Szeged, Hungary.
Neurosci Lett. 2004 Mar 4;357(2):131-4. doi: 10.1016/j.neulet.2003.12.046.
The aim of this study was to investigate lateral connectivity in early visual cortex of schizophrenia patients. Contrast thresholds were measured for centrally presented Gabor patches which were surrounded by two collinear or orthogonal flankers. The healthy subjects (n = 15) showed lower contrast thresholds for central Gabor patches when collinear flankers were presented. This effect was significantly reduced in unmedicated highly functioning schizophrenia patients (n = 20) who performed normally on the continuous performance test. The performance of the patients did not correlate with the positive and negative symptoms. The facilitation effect of collinear flankers is believed to reflect lateral interactions between feature-specific units in early visual cortex (V1). Our results therefore suggest abnormal lateral interactions in early visual cortex of schizophrenia patients.
本研究的目的是调查精神分裂症患者早期视觉皮层的侧向连接性。测量了中央呈现的Gabor斑块的对比度阈值，这些斑块被两个共线或正交的侧翼包围。当呈现共线侧翼时，健康受试者（n = 15）对中央Gabor斑块的对比度阈值较低。在连续性能测试中表现正常的未用药高功能精神分裂症患者（n = 20）中，这种效应显著降低。患者的表现与阳性和阴性症状无关。共线侧翼的促进作用被认为反映了早期视觉皮层（V1）中特征特异性单元之间的侧向相互作用。因此，我们的结果表明精神分裂症患者早期视觉皮层存在异常的侧向相互作用。
