Rispoli Vincenzo, Rotiroti Domenicantonio, Carelli Vincenzo, Liberatore Felice, Scipione Luigi, Marra Rosario, Giorgioni Gianfabio, Di Stefano Antonio
Department of Scienze Farmacobiologiche, University of Catanzaro Magna Graecia, Complesso Ninì Barbieri, 88021 Roccelletta di Borgia (CZ), Italy.
Neurosci Lett. 2004 Feb 19;356(3):199-202. doi: 10.1016/j.neulet.2003.11.054.
The effects of two choline pivaloyl esters, [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium iodide (1) and [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium 2,2-dimethylpropionate (2), on learning and memory impairments induced in rats by scopolamine or lesions of nucleus basalis magnocellularis (NBM) have been evaluated by object recognition and Morris water maze tests in comparison with Tacrine (THA). Both 1 and 2 restored discrimination in object recognition test for assessing working-episodic memory and improved spatial memory in scopolamine or NBM-lesioned rats as well. The positive effects produced by 1 and 2 on cognitive and memory deficits were well comparable with those evoked by THA, used as reference compound.
通过物体识别和莫里斯水迷宫试验，与他克林（THA）相比，评估了两种新戊酰胆碱酯，即[2-(2,2-二甲基丙酰氧基)乙基]三甲基碘化铵（1）和[2-(2,2-二甲基丙酰氧基)乙基]三甲基丙酸酯（2）对东莨菪碱或大细胞基底核（NBM）损伤诱导的大鼠学习和记忆障碍的影响。1和2均恢复了用于评估工作情景记忆的物体识别试验中的辨别能力，并且也改善了东莨菪碱或NBM损伤大鼠的空间记忆。1和2对认知和记忆缺陷产生的积极作用与用作参考化合物的THA所引起的作用相当。
