Chan T Y, Chan J C, Tomlinson B, Critchley J A
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
Drug Saf. 1992 May-Jun;7(3):235-40. doi: 10.2165/00002018-199207030-00008.
To determine the pattern of and the risk factors for adverse drug reactions (ADRs) in Hong Kong, a prospective study of acute admissions to 2 general medical wards at the Prince of Wales Hospital was undertaken. Of the 1701 admissions included in this study, 74 (4.4%) were attributed to ADRs. Sulphonylureas, nonsteroidal anti-inflammatories (NSAIDs) and insulin accounted for 61% of cases. The most frequent ADRs were hypoglycaemia (43%) and gastrointestinal haemorrhage (29.7%). Both old age and impaired renal function appear to be important risk factors for ADRs. In such situations, careful dose adjustments, use of an alternative drug or total avoidance may be necessary. Particular attention should be given to oral hypoglycaemic drugs and NSAIDs.
为确定香港地区药物不良反应（ADR）的模式及危险因素，对威尔士亲王医院2个普通内科病房的急性入院患者进行了一项前瞻性研究。本研究纳入的1701例入院患者中，74例（4.4%）归因于药物不良反应。磺脲类药物、非甾体抗炎药（NSAIDs）和胰岛素占病例的61%。最常见的药物不良反应是低血糖（43%）和胃肠道出血（29.7%）。老年和肾功能损害似乎都是药物不良反应的重要危险因素。在这种情况下，可能需要仔细调整剂量、使用替代药物或完全避免用药。应特别关注口服降糖药和非甾体抗炎药。
