Anteby Eyal Y, Musalam Banan, Milwidsky Ariel, Blumenfeld Anat, Gilis Shmuel, Valsky Dan, Hamani Yaron
Department of Obstetrics and Gynecology, Hadassah University Hospital, P.O. Box 24035, Mt. Scopus, Jerusalem, Israel.
Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15;113(1):31-5. doi: 10.1016/j.ejogrb.2003.05.002.
To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.
A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.
A university hospital with 3700 deliveries per year.
Seventy cases with severe preeclampsia, IUGR or placental abruption.
Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.
Gestational age at delivery, birth weight and early neonatal complications.
Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.
Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity.
确定胎儿常见的遗传性血栓形成倾向是否会影响重度子痫前期、胎儿生长受限（IUGR）及胎盘早剥的严重程度。
一项针对妊娠并发症患者的病例对照研究。病例定义为患有血栓形成倾向的胎儿。
一家每年有3700例分娩的大学医院。
70例患有重度子痫前期、胎儿生长受限或胎盘早剥的病例。
对母亲和新生儿进行凝血因子V莱顿突变、凝血酶原基因及亚甲基四氢叶酸还原酶的检测。
分娩时的孕周、出生体重及早期新生儿并发症。
与对照胎儿相比，携带凝血因子V莱顿或凝血酶原基因突变的胎儿，其分娩时的孕周及出生体重显著更低。
胎儿凝血因子V莱顿突变和凝血酶原基因突变可能会影响重度子痫前期、胎儿生长受限及胎盘早剥的病程。这些血栓形成倾向的改变可能会导致更早出现或引发更严重的晚期妊娠并发症。
