Abt K, Gülich A, Krupp P, Reinberg W
Department of Biomathematics, University of Frankfurt, Federal Republic of Germany.
Drug Saf. 1992;7 Suppl 1:10-6. doi: 10.2165/00002018-199200071-00006.
This paper describes a statistical analysis of the simultaneous occurrence of 48 human leucocyte antigens (HLAs) in an attempt to predict whether a patient treated with clozapine will develop granulocytopenia or agranulocytosis. Whereas the numerical results show that use of HLAs does not appear to satisfy the intended purpose, emphasis is placed on the statistical methodology recommended for a problem of this type. Other work in this area is critically discussed.
本文描述了对48种人类白细胞抗原（HLA）同时出现情况的统计分析，旨在预测接受氯氮平治疗的患者是否会发生粒细胞减少或粒细胞缺乏症。虽然数值结果表明使用HLA似乎无法达到预期目的，但重点在于为此类问题推荐的统计方法。对该领域的其他研究进行了批判性讨论。
