Hummer M, Sperner-Unterweger B, Kemmler G, Falk M, Kurz M, Oberbauer H, Fleischhacker W W
Department of Biological Psychiatry, Innsbruck University Clinics, Austria.
Psychopharmacology (Berl). 1996 Mar;124(1-2):201-4. doi: 10.1007/BF02245622.
The atypical antipsychotic clozapine carries a high risk of inducing agranulocytosis. We attempted to investigate whether eosinophilia during clozapine treatment has predictive value for subsequent neutropenia/agranulocytosis. One hundred and seventy-seven patients were studied in a prospective naturalistic design using haloperidol as the reference compound. Clozapine was found to differ from haloperidol in respect to their influence on neutrophil granulocytes. In the clozapine group patients with eosinophilia showed a decrease in neutrophil count (less than 2000/mm3 neutrophil granulocytes) significantly more often than patients without eosinophilia.
非典型抗精神病药物氯氮平有诱发粒细胞缺乏症的高风险。我们试图研究氯氮平治疗期间的嗜酸性粒细胞增多症是否对随后的中性粒细胞减少症/粒细胞缺乏症具有预测价值。采用前瞻性自然观察设计，以氟哌啶醇作为对照化合物，对177例患者进行了研究。结果发现，氯氮平和氟哌啶醇对中性粒细胞的影响有所不同。在氯氮平组中，出现嗜酸性粒细胞增多症的患者中性粒细胞计数下降（中性粒细胞少于2000/mm³）的情况明显比未出现嗜酸性粒细胞增多症的患者更常见。
