一名处于慢性期慢性髓性白血病（CML）患者在服用甲磺酸伊马替尼期间出现伴有CML细胞皮肤浸润的Sweet综合征。

Sweet's syndrome with CML cell infiltration of the skin in a patient with chronic-phase CML while taking Imatinib Mesylate.

作者信息

Liu Delong, Seiter Karen, Mathews Thomas, Madahar Cecily J, Ahmed Tauseef

机构信息

New York Medical College and Zalmen A. Arlin Cancer Institute, Room 250, Munger Pavilion, Valhalla, NY 10595, USA.

出版信息

Leuk Res. 2004 May;28 Suppl 1:S61-3. doi: 10.1016/S0145-2126(03)00257-1.

DOI:10.1016/S0145-2126(03)00257-1

PMID:15036943

Abstract

Sweet's syndrome (acute febrile neutrophilic dermatosis) is characterized by an acute onset of erythematous plaques, fever, and leukocytosis. This syndrome has been reported to be associated with leukemia including chronic myelogenous leukemia (CML). Sweet's syndrome seen in patients with leukemia is usually associated with active and/or refractory disease. Imatinib Mesylate (STI-571, Gleevec) is widely used for therapy of CML. In this case report, CML cell infiltration of the skin was documented by fluorescence in situ hybridization (FISH) analysis in a patient with chronic-phase CML on Imatinib Mesylate (STI-571, Gleevec), who was at the time in molecular remission.

摘要

斯威特综合征（急性发热性嗜中性皮病）的特征为急性起病的红斑性斑块、发热和白细胞增多。据报道，该综合征与包括慢性粒细胞白血病（CML）在内的白血病有关。白血病患者中出现的斯威特综合征通常与疾病的活动期和/或难治性相关。甲磺酸伊马替尼（STI-571，格列卫）广泛用于慢性粒细胞白血病的治疗。在本病例报告中，一名处于慢性期的慢性粒细胞白血病患者正在接受甲磺酸伊马替尼（STI-571，格列卫）治疗，当时处于分子缓解期，通过荧光原位杂交（FISH）分析记录到其皮肤存在慢性粒细胞白血病细胞浸润。