Davies Sean S, Amarnath Venkataraman, Roberts L Jackson
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602, USA.
Chem Phys Lipids. 2004 Mar;128(1-2):85-99. doi: 10.1016/j.chemphyslip.2003.10.007.
Oxidation of arachidonic acid leads to the formation of highly reactive gamma-ketoaldehydes now termed isoketals. Isoketals react with proteins at a rate that far exceeds other well studied products of lipid peroxidation such as 4-hydroxynonenal and demonstrate a remarkable proclivity to crosslink these proteins. For these reasons, isoketals have the potential to significantly alter protein function and contribute to disease processes. This article reviews the chemistry of isoketal formation, of their adduction to proteins, and of their proclivity to crosslink proteins, as well as their effects on protein function, and their potential role in diseases associated with oxidative injury.
花生四烯酸的氧化会导致形成现在被称为异酮缩醛的高反应性γ-酮醛。异酮缩醛与蛋白质反应的速率远远超过脂质过氧化的其他已深入研究的产物，如4-羟基壬烯醛，并且显示出显著的交联这些蛋白质的倾向。由于这些原因，异酮缩醛有可能显著改变蛋白质功能并促成疾病进程。本文综述了异酮缩醛的形成化学、它们与蛋白质的加成反应、它们交联蛋白质的倾向、它们对蛋白质功能的影响以及它们在与氧化损伤相关疾病中的潜在作用。
