Chen L, Shao H J, Su Y B
The Key Laboratory of Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, PR China.
Int Immunopharmacol. 2004 Mar;4(3):403-9. doi: 10.1016/j.intimp.2003.12.015.
DNA vaccines induce protective humoral and cell-mediated immune responses in several animal models. Agaricus blazei Murill (ABM) is particularly rich in polysaccharides, and has shown particularly strong results in treating and preventing cancers. The goal of this study was to investigate whether co-immunization of the fungus ABM with hepatitis B virus (HBV) core DNA vaccine could increase the immune responses. Compared with the control mice which received hepatitis B virus core antigen (HBcAg) alone, significant increase in not only the HBcAg-specific antibody response but also T cell proliferation was observed in mice which received HBcAg DNA vaccine plus ABM extract. These results suggest that ABM extract might represent an adjuvant to improve the efficacy of DNA vaccines in vivo.
DNA疫苗在多种动物模型中可诱导产生保护性体液免疫和细胞介导的免疫反应。姬松茸（ABM）富含多糖，在癌症治疗和预防方面显示出特别显著的效果。本研究的目的是探讨将真菌ABM与乙型肝炎病毒（HBV）核心DNA疫苗联合免疫是否能增强免疫反应。与单独接受乙型肝炎病毒核心抗原（HBcAg）的对照小鼠相比，接受HBcAg DNA疫苗加ABM提取物的小鼠不仅HBcAg特异性抗体反应显著增加，而且T细胞增殖也显著增加。这些结果表明，ABM提取物可能是一种可提高DNA疫苗体内疗效的佐剂。
