Parent Carole A
Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bldg37/Rm1E24, Bethesda MD 20892-4255, USA.
Curr Opin Cell Biol. 2004 Feb;16(1):4-13. doi: 10.1016/j.ceb.2003.11.008.
Neutrophils and Dictyostelium discoideum share the ability to migrate directionally in response to external chemoattractant gradients. The binding of chemoattractants to specific receptors that are coupled to heterotrimeric G proteins leads to a wide range of biochemical responses that become highly localized as cells polarize and migrate by chemotaxis. The signaling mechanisms that lead to the predominant polymerization of F-actin at the front of cells for propulsion and to myosin II assembly at the sides to suppress lateral pseudopod formation and at the back for retraction are now beginning to emerge.
中性粒细胞和盘基网柄菌都具有响应外部趋化因子梯度进行定向迁移的能力。趋化因子与偶联异源三聚体G蛋白的特定受体结合，会引发一系列生化反应，随着细胞通过趋化作用极化和迁移，这些反应会高度局部化。导致F-肌动蛋白在细胞前端主要聚合以实现推进、在细胞侧面组装肌球蛋白II以抑制侧向伪足形成以及在细胞后端组装以实现收缩的信号传导机制，目前正逐渐明晰。
