Amos Linda A, van den Ent Fusinita, Löwe Jan
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Curr Opin Cell Biol. 2004 Feb;16(1):24-31. doi: 10.1016/j.ceb.2003.11.005.
Structural proteins are now known to be as necessary for controlling cell division and cell shape in prokaryotes as they are in eukaryotes. Bacterial ParM and MreB not only have atomic structures that resemble eukaryotic actin and form similar filaments, but they are also equivalent in function: the assembly of ParM drives intracellular motility and MreB maintains the shape of the cell. FtsZ resembles tubulin in structure and in its dynamic assembly, and is similarly controlled by accessory proteins. Bacterial MinD and eukaryotic dynamin appear to have similar functions in membrane control. In dividing eukaryotic organelles of bacterial origin, bacterial and eukaryotic proteins work together.
现在已知结构蛋白对于原核生物控制细胞分裂和细胞形状而言，与在真核生物中一样必不可少。细菌的ParM和MreB不仅具有类似于真核肌动蛋白的原子结构并形成相似的细丝，而且它们在功能上也是等效的：ParM的组装驱动细胞内运动，而MreB维持细胞形状。FtsZ在结构及其动态组装方面类似于微管蛋白，并且同样受辅助蛋白的控制。细菌的MinD和真核动力蛋白在膜控制方面似乎具有相似的功能。在源自细菌的真核细胞器分裂过程中，细菌蛋白和真核蛋白协同发挥作用。
