Samuel U, Guggenbichler J P
Department of Urology, The University of Erlangen, Loschgestr. 15, 91054 Erlangen, Germany.
Int J Antimicrob Agents. 2004 Mar;23 Suppl 1:S75-8. doi: 10.1016/j.ijantimicag.2003.12.004.
Contaminated or infected catheters are a major source of nosocomial infections responsible for >40% of all episodes of nosocomial sepsis in acute-care hospitals. Antibiotics as well as surface modifications with, for example, hydrogels proved to be of little value in preventing the contamination of indwelling catheters. The even distribution of 10(12-13) activated silver nanoparticles per gram in various polymers, e.g. polyurethane and silicone, results in an excellent antimicrobial activity against a broad spectrum of organisms in vitro. Substantial reduction of incrustation of these catheters was also observed. These preliminary experimental data warrant clinical studies.
受污染或感染的导管是医院感染的主要来源，在急症医院中，其导致的医院败血症发作占所有病例的40%以上。抗生素以及诸如水凝胶等表面改性方法在预防留置导管污染方面被证明效果甚微。每克各种聚合物（如聚氨酯和硅酮）中均匀分布10(12 - 13)个活化银纳米颗粒，在体外对多种生物体具有出色的抗菌活性。还观察到这些导管的结痂现象大幅减少。这些初步实验数据为临床研究提供了依据。
