海马硬化病例中颞叶前部T2时间延长：3T多回波T2弛豫测量研究
Increased anterior temporal lobe T2 times in cases of hippocampal sclerosis: a multi-echo T2 relaxometry study at 3 T.
作者信息
Briellmann Regula S, Syngeniotis Ari, Fleming Steve, Kalnins Renate M, Abbott David F, Jackson Graeme D
机构信息
Brain Research Institute, Austin Health, Repatriation Campus, Heidelberg, Victoria 3081, Australia.
出版信息
AJNR Am J Neuroradiol. 2004 Mar;25(3):389-94.
BACKGROUND AND PURPOSE
Increased T2 relaxation times in the ipsilateral hippocampus are present in patients with hippocampal sclerosis. Visual assessment of T2-weighted images of these patients suggests increased signal intensity in the anterior temporal lobe as well. Our aim was to assess hippocampal and anterior temporal T2 relaxation times in patients with partial epilepsy by using a new T2-relaxometry sequence implemented by using a 3-T General Electric imaging unit.
METHODS
Coronal view T2 maps were generated by using an eight-echo Carr-Purcell-Meiboom-Gill sequence (TE, 28-231) with an acquisition time of 7 min on a 3-T General Electric Signa Horizon LX imaging unit. T2 relaxation times were measured in the hippocampus and anterior temporal lobe of 30 healthy control volunteers and 20 patients with partial epilepsy.
RESULTS
For the 30 control volunteers, the mean hippocampal T2 relaxation time was 98 +/- 2.8 ms. In all measured areas, the asymmetry index was small (<0.01). For the 15 patients with independent evidence of hippocampal sclerosis established by visual, volumetric, and, when available, pathologic criteria, mean hippocampal T2 relaxation times were 118 +/- 7 ms (P <.0001) on the ipsilateral side and 101 +/- 4 ms (P =.005) on the contralateral side. The T2 values were also increased in the anterior temporal lobe (ipsilateral: 82 +/- 6 ms, P <.0001; contralateral: 79 +/- 6 ms, P =.01) as compared with the values for the control volunteers (75 +/- 3 ms). The five patients with focal cortical dysplasia had hippocampal T2 relaxation times that were not different from control values.
CONCLUSION
T2 relaxometry at 3 T is feasible and useful and confirmed marked ipsilateral hippocampal signal intensity increase in patients with hippocampal sclerosis. Importantly, definite signal intensity change was also present in the anterior temporal lobe. T2 relaxometry is a sensitive means of identifying abnormalities in the hippocampus and other brain structures.
背景与目的
海马硬化患者同侧海马的T2弛豫时间延长。对这些患者T2加权图像的视觉评估显示颞叶前部信号强度也增加。我们的目的是通过使用3-T通用电气成像设备实施的一种新的T2弛豫测量序列，评估部分癫痫患者海马和颞叶前部的T2弛豫时间。
方法
在3-T通用电气Signa Horizon LX成像设备上，使用八回波Carr-Purcell-Meiboom-Gill序列（TE，28 - 231）生成冠状面T2图，采集时间为7分钟。测量了30名健康对照志愿者和20名部分癫痫患者海马及颞叶前部的T2弛豫时间。
结果
对于30名对照志愿者，海马的平均T2弛豫时间为98±2.8毫秒。在所有测量区域，不对称指数较小（<0.01）。对于15名通过视觉、体积测量以及必要时的病理标准确定有海马硬化独立证据的患者，同侧海马的平均T2弛豫时间为118±7毫秒（P<.0001），对侧为101±4毫秒（P =.005）。与对照志愿者的值（75±3毫秒）相比，颞叶前部的T2值也增加（同侧：82±6毫秒，P<.0001；对侧：79±6毫秒，P =.01）。5名局灶性皮质发育不良患者的海马T2弛豫时间与对照值无差异。
结论
3-T的T2弛豫测量可行且有用，证实了海马硬化患者同侧海马信号强度明显增加。重要的是，颞叶前部也存在明确的信号强度变化。T2弛豫测量是识别海马和其他脑结构异常的一种敏感方法。
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