成像相关生物标志物在人类癫痫发生中的研究前景：一项批判性综述。
Prospects for imaging-related biomarkers of human epileptogenesis: a critical review.
机构信息
Comprehensive Epilepsy Management Center, Montefiore Medical Center, 111 E. 210th St, Bronx, NY 10467, USA.
出版信息
Biomark Med. 2011 Oct;5(5):599-606. doi: 10.2217/bmm.11.66.
Abstract
To facilitate the study of epileptogenesis in humans, noninvasive biomarkers of epileptogenesis are required. No validated biomarker is currently available, but brain imaging techniques provide many attractive candidates. In this article we examine the imaging features of temporal lobe epilepsy, focusing on those that may precede the onset of epilepsy and correlate with epileptogenesis. Hippocampal volumetry and T(2) relaxometry are proposed as candidate biomarkers of epileptogenesis in temporal lobe epilepsy following febrile status epilepticus. Preliminary data suggest that these have promise, and the ongoing Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study will provide more conclusive evidence as to their validity. At this time there are no other clear candidates for imaging-related biomarkers of epileptogenesis in human studies.
摘要
为了促进人类癫痫发生的研究，需要非侵入性的癫痫发生生物标志物。目前尚无经过验证的生物标志物，但脑成像技术提供了许多有吸引力的候选者。本文检查了颞叶癫痫的影像学特征，重点是那些可能在癫痫发作之前出现并与癫痫发生相关的特征。海马体积测量和 T2 弛豫率被提议作为热惊厥后颞叶癫痫癫痫发生的候选生物标志物。初步数据表明这些有希望，正在进行的儿童热性惊厥持续时间的后果（FEBSTAT）研究将为其有效性提供更确凿的证据。目前，在人类研究中，没有其他明确的癫痫发生影像学相关生物标志物的候选者。
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