Lo Chung-Ping, Chen Cheng-Yu, Chin Shy-Chyi, Juan Chun-Jung, Hsueh Chun-Jen, Chen Ann
Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, 325 Sec. 2 Cheng-Kung Road, Neihu 114, Taipei, Taiwan, Republic of China.
AJNR Am J Neuroradiol. 2004 Mar;25(3):415-8.
Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced T1-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion.
戈勒姆病是一种罕见疾病，其特征为血管瘤组织在骨内发生肿瘤性增殖，并伴有进行性、广泛性骨质溶解。我们报告一例经病理证实的戈勒姆病病例，该病例发生于一名23岁男性的左顶骨。包括头颅常规X线摄影、CT、磁共振成像（MR成像）及锝-99m（Tc-99m）闪烁扫描在内的影像学检查显示，左顶骨处存在一个大的颅骨缺损，且无相关软组织肿块。钆增强T1加权MR成像及Tc-99m亚甲基二膦酸盐（Tc-99m MDP）骨闪烁扫描显示，缺损边缘有对比增强及同位素摄取增加。病理研究显示，溶骨性颅骨病变周边存在骨内血管瘤病。
