Pazzaglia U E, Andrini L, Bonato M, Leutner M
Clinica Ortopedica, 2a Facoltà di Medicine e Chirurgia, Università di Pavia, Varese, Italy.
Int Orthop. 1997;21(5):303-7. doi: 10.1007/s002640050173.
A case of disappearing bone disease of the proximal femur is reported with histopathological and immunohistochemical studies. There was a densely packed cellular tissue, positive to endothelial antibodies, in areas of massive bone destruction. A more differentiated vascular tissue was present where trabecular cancellous or cortical bone was preserved with only focal zones of accelerated bone remodelling. The self-limited course correlates well with two phases of evolution of the histopathological lesions with neoplastic-like proliferation of endothelial cells corresponding to the rapid and massive bone destruction, and a later differentiation of the cells in mature vascular structures, but still with accelerated bone resorption which is partly compensated by appositional activity.
报告了一例股骨近端骨质消失疾病，并进行了组织病理学和免疫组织化学研究。在大量骨质破坏区域存在紧密堆积的细胞组织，对内皮抗体呈阳性。在小梁松质骨或皮质骨保存且仅有局部加速骨重塑区域存在更分化的血管组织。自限性病程与组织病理学病变的两个演变阶段密切相关，内皮细胞的肿瘤样增殖对应快速且大量的骨质破坏，随后细胞分化为成熟血管结构，但仍有加速的骨吸收，部分由沉积活动代偿。
