Nürnberger J, Opazo Saez A, Mitchell A, Bührmann S, Wenzel R R, Siffert W, Philipp T, Schäfers R F
Department of Nephrology and Hypertension, Essen, Germany.
J Hum Hypertens. 2004 Apr;18(4):267-71. doi: 10.1038/sj.jhh.1001665.
Arterial stiffening is the major cause of increasing systolic blood pressure in arterial hypertension. Increased arterial stiffness is one major mechanism responsible for morbidity and mortality in hypertension. A C825T polymorphism was identified in the gene encoding the G-protein beta3 subunit (GNB3), and an association of the T-allele with hypertension was demonstrated in several studies. In order to identify a pathogenetic link between hypertension and arterial stiffness, we compared two indices of arterial stiffness, pulse wave velocity (PWV) and augmentation index, in young, healthy men with and without the 825T-allele under resting conditions. PWV was determined from pressure tracing over carotid and femoral arteries in 99 subjects (CC: n=43; CT&TT: n=56). Augmentation index was derived in 72 subjects (CC: n=30; CT&TT: n=42) by pulse wave analysis using radial applanation tonometry. Carriers of the 825T-allele exhibited a significantly higher PWV compared to subjects with the CC genotype (6.0+/-0.1 m/s (TC&TT) vs 5.7+/-0.1 m/s (CC); P=0.0251). There was also a significant difference (P = 0.0448) in augmentation index between carriers of the T-allele (CT&TT: 3.4+/-2.9%) and controls with the CC -genotype (-5.0+/-4.1 %). There was no difference in any other anthropometric (age, height, weight, body mass index) or haemodynamic (heart rate, peripheral and central blood pressure). In summary, the C825T polymorphism is associated with higher arterial stiffness in young, healthy males. Arterial stiffening may pathogenetically contribute to the development of hypertension in carriers of the T-allele.
动脉僵硬度增加是动脉性高血压患者收缩压升高的主要原因。动脉僵硬度增加是高血压患者发病和死亡的主要机制之一。在编码G蛋白β3亚基（GNB3）的基因中发现了一个C825T多态性，多项研究证实T等位基因与高血压有关。为了确定高血压与动脉僵硬度之间的发病机制联系，我们比较了静息状态下有和没有825T等位基因的年轻健康男性的两个动脉僵硬度指标，即脉搏波速度（PWV）和增强指数。对99名受试者（CC基因型：n = 43；CT&TT基因型：n = 56）进行颈动脉和股动脉压力描记来测定PWV。通过使用桡动脉压平式张力测定法进行脉搏波分析，在72名受试者（CC基因型：n = 30；CT&TT基因型：n = 42）中得出增强指数。与CC基因型受试者相比，825T等位基因携带者的PWV显著更高（6.0±0.1 m/s（TC&TT）对5.7±0.1 m/s（CC）；P = 0.0251）。T等位基因携带者（CT&TT：3.4±2.9%）与CC基因型对照组（-5.0±4.1%）之间的增强指数也存在显著差异（P = 0.0448）。在任何其他人体测量指标（年龄、身高、体重、体重指数）或血流动力学指标（心率、外周和中心血压）方面均无差异。总之，C825T多态性与年轻健康男性较高的动脉僵硬度有关。动脉僵硬度增加可能在发病机制上促使T等位基因携带者发生高血压。
