Logan Jeongok G, Engler Mary B, Kim Hyungsuk
School of Nursing, University of Virginia, 225 Jeanette Lancaster Way, Charlottesville, VA, 22903-3388, USA,
J Cardiovasc Transl Res. 2015 Feb;8(1):23-43. doi: 10.1007/s12265-014-9597-x. Epub 2014 Dec 4.
Stiffness of large arteries (called arteriosclerosis) is an independent predictor of cardiovascular morbidity and mortality. Although previous studies have shown that arterial stiffness is moderately heritable, genetic factors contributing to arterial stiffness are largely unknown. In this paper, we reviewed the available literature on genetic variants that are potentially related to arterial stiffness. Most variants have shown mixed depictions of their association with arterial stiffness across multiple studies. Various methods to measure arterial stiffness at different arterial sites can contribute to these inconsistent results. In addition, studies in patient populations with hypertension or atherosclerosis may overestimate the impact of genetic variants on arterial stiffness. Future studies are recommended to standardize current measures of arterial stiffness in different age groups. Studies conducted in normal healthy subjects may also provide better opportunities to find novel genetic variants of arterial stiffness.
大动脉僵硬度（称为动脉硬化）是心血管疾病发病率和死亡率的独立预测指标。尽管先前的研究表明动脉僵硬度具有中度遗传性，但导致动脉僵硬度的遗传因素在很大程度上尚不清楚。在本文中，我们回顾了关于可能与动脉僵硬度相关的基因变异的现有文献。大多数变异在多项研究中对其与动脉僵硬度的关联呈现出混合的描述。在不同动脉部位测量动脉僵硬度的各种方法可能导致这些不一致的结果。此外，在高血压或动脉粥样硬化患者群体中的研究可能高估了基因变异对动脉僵硬度的影响。建议未来的研究对不同年龄组的当前动脉僵硬度测量方法进行标准化。在正常健康受试者中进行的研究也可能为发现动脉僵硬度的新基因变异提供更好的机会。
