Camicioli Richard, Fisher Nancy
Department of Medicine, Division of Neurology, University of Alberta, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada.
Can J Neurol Sci. 2004 Feb;31(1):7-21. doi: 10.1017/s0317167100002791.
Dementia occurs in up to 30% of people with Parkinson's disease and is a major cause of disability. Pathologically, Parkinson's dementia, where dementia follows the onset of parkinsonism by at least one year, overlaps with dementia with Lewy bodies. We review the functional impact, definitions, neuropsychology, epidemiology and pathophysiology of Parkinson's dementia, dementia with Lewy bodies and their overlap. Associated psychiatric and imaging findings are also considered. Lastly, current and emerging approaches to assessment and treatment in patients with these Lewy body associated dementias are presented.
高达30%的帕金森病患者会出现痴呆症，这是导致残疾的主要原因。在病理学上，帕金森病痴呆（痴呆症在帕金森综合征发病至少一年后出现）与路易体痴呆症有重叠。我们综述了帕金森病痴呆、路易体痴呆及其重叠情况的功能影响、定义、神经心理学、流行病学和病理生理学。还考虑了相关的精神科和影像学发现。最后，介绍了目前以及新出现的针对这些路易体相关痴呆症患者的评估和治疗方法。
