Lim Youngwook, Yang Jiyeon, Kim Youngsoo, Chang Yoonseok, Shin Dongchun
Dept. of Environmental Health, Seonam University, 720 Gwangchi-dong, Namwon, Jeonbuk, Korea.
Environ Monit Assess. 2004 Mar;92(1-3):211-28. doi: 10.1023/b:emas.0000014502.77263.57.
This study assessed the daily exposure to dioxin using comparable approach methods in order to predict the human health risks of dioxin on the general adult population and incinerator workers in Korea. The health risk assessment of dioxin involved four scenarios (General-Direct, General-Breast Milk, General-Blood, and Worker-Blood). The risks were described in terms of the excess cancer risk and the MOEs (Margin-Of-Exposure) for cancer, reproductive dysfunctions, endometriosis, and neurobehavioral effects. The adult daily intake (General-Direct) of dioxin was estimated to be 0.50 pg-TEQ/kg-day based on the dioxin concentrations in the environmental media and foods in Korea. The average dioxin concentrations in General-Breast Milk, General-Blood, and Worker-Blood were 15.13 pg-TEQ/g fat, 14.57 pg-TEQ/g lipid, and 22.90 pg-TEQ/g lipid, respectively. The lifetime average daily doses (LADDs) of dioxin for General-Breast Milk, General-Blood, and Worker-Blood were estimated to be 1.35 pg-TEQ/kg day, 0.99 pg-TEQ/kg day, and 1.15 pg-TEQ/kg day, respectively. Although the estimated risks of cancer and reproductive dysfunctions were not unusually high in any of the four scenarios, the MOE values for the neurobehavioral effects on infants were not sufficiently high to guarantee the safety against this endpoint.
本研究采用可比方法评估了二噁英的每日暴露量，以预测二噁英对韩国普通成年人群和垃圾焚烧厂工人的人体健康风险。二噁英的健康风险评估涉及四种情景（普通-直接、普通-母乳、普通-血液和工人-血液）。风险通过超额癌症风险以及癌症、生殖功能障碍、子宫内膜异位症和神经行为影响的暴露边际（MOE）来描述。根据韩国环境介质和食品中的二噁英浓度，估计成年人每日二噁英摄入量（普通-直接）为0.50 pg-TEQ/kg-天。普通-母乳、普通-血液和工人-血液中二噁英的平均浓度分别为15.13 pg-TEQ/g脂肪、14.57 pg-TEQ/g脂质和22.90 pg-TEQ/g脂质。普通-母乳、普通-血液和工人-血液中二噁英的终生平均每日剂量（LADDs）估计分别为1.35 pg-TEQ/kg天、0.99 pg-TEQ/kg天和1.15 pg-TEQ/kg天。尽管在四种情景中的任何一种情景下，估计的癌症和生殖功能障碍风险都不是特别高，但婴儿神经行为影响的MOE值不足以确保针对该终点的安全性。
