Li Jingguang, Zhang Lei, Wu Yongning, Liu Yinping, Zhou Pingping, Wen Sheng, Liu Jiaying, Zhao Yunfeng, Li Xiaowei
National Institute of Nutrition and Food Safety, 29 Nanwei Road, Beijing 100050, China.
Chemosphere. 2009 May;75(9):1236-42. doi: 10.1016/j.chemosphere.2009.01.073. Epub 2009 Feb 28.
The study examined the levels of dioxin-like compounds in 24 pooled samples that were comprised of 1237 individual human milk samples from 12 provinces of China. The samples were taken in different regions to evaluate the body burden of these contaminants and assess their health risk to breast-feeding infants of China. The pooled samples were analyzed for 17 polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and 12 dioxin-like polychlorinated biphenyls (dl-PCBs) congeners. The population of the provinces involved in this study accounts for approximately 50% of the total Chinese population. The range of upper-bound total-TEQ in samples was from 2.59 pg TEQ g(-1) lipid to 9.92 pg TEQ g(-1) lipid with a mean of 5.42 pg TEQ g(-1) lipid and a median of 5.11 pg TEQ g(-1) lipid. PCDD/Fs-TEQ and total-TEQ in human milk from rural areas were lower than those from urban areas. The positive correlations were found between total-TEQ level in human milk and the consumption of aquatic food and meat respectively. The mean estimated daily intake of PCDD/Fs and dl-PCBs by infants was 28.0 pg TEQ kg(-1) bw per day with a range from 14.2 pg TEQ kg(-1) bw per day to 48.6 pg TEQ kg(-1) bw per day. In the study, both the TEQ body burden of the sample population and estimated daily TEQ intake of breast-feeding infants were lower than those of developed countries. Continuous surveillance on PCDD/Fs and dl-PCBs levels in human milk is needed to correctly evaluate both the environmental impact and human health risk in China.
该研究检测了24个混合样本中的二噁英类化合物水平，这些样本由来自中国12个省份的1237份个体母乳样本组成。样本取自不同地区，以评估这些污染物的人体负荷，并评估其对中国母乳喂养婴儿的健康风险。对混合样本分析了17种多氯代二苯并 - 对 - 二噁英和二苯并呋喃（PCDD/Fs）以及12种二噁英类多氯联苯（dl-PCBs）同系物。参与本研究的省份人口约占中国总人口的50%。样本中上限总毒性当量（TEQ）的范围为2.59 pg TEQ g(-1)脂质至9.92 pg TEQ g(-1)脂质，平均值为5.42 pg TEQ g(-1)脂质，中位数为5.11 pg TEQ g(-1)脂质。农村地区母乳中的PCDD/Fs-TEQ和总TEQ低于城市地区。母乳中总TEQ水平分别与水产品和肉类的消费量呈正相关。婴儿对PCDD/Fs和dl-PCBs的平均估计每日摄入量为28.0 pg TEQ kg(-1)体重/天，范围为14.2 pg TEQ kg(-1)体重/天至48.6 pg TEQ kg(-1)体重/天。在该研究中，样本人群的TEQ人体负荷以及母乳喂养婴儿的估计每日TEQ摄入量均低于发达国家。需要持续监测母乳中PCDD/Fs和dl-PCBs的水平，以正确评估中国的环境影响和人类健康风险。
