Cooper J D, Schoen R T
Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510-8056.
Curr Opin Rheumatol. 1992 Aug;4(4):520-8.
Lyme disease is the most common vector-borne disease in the United States. Epidemiologic research has contributed to a better understanding of the factors involved in the geographic spread and increased incidence of the disease. Clinical features of Lyme disease, including skin, joint, cardiac, and neurologic involvement, are discussed here, along with recent studies that better characterize these clinical manifestations and more clearly define their immunopathogenesis. The diagnosis of Lyme disease is based on the clinical presentation. Laboratory testing may be helpful but has significant limitations, which we discuss in our review.
莱姆病是美国最常见的媒介传播疾病。流行病学研究有助于更好地理解该疾病地理传播和发病率增加所涉及的因素。本文讨论了莱姆病的临床特征，包括皮肤、关节、心脏和神经系统受累情况，以及最近能更好地表征这些临床表现并更清晰地界定其免疫发病机制的研究。莱姆病的诊断基于临床表现。实验室检测可能有帮助，但有显著局限性，我们将在综述中讨论这些局限性。
