Pacheco Eugenia, Fonseca Carolina, Montes Carlos, Zabaleta Jovanny, García Luis F, Arias Mauricio A
Grupo de Inmunología Celular e Inmunogenética, Facultad de Medicina, Universidad de Antioquia, Cra 51 D No 62-29 Lab 283 Medellín, Colombia.
FEMS Immunol Med Microbiol. 2004 Apr 9;40(3):207-13. doi: 10.1016/S0928-8244(03)00369-9.
Mycobacterium tuberculosis interacts with monocyte-macrophages through cell surface molecules including CD14. A soluble form of CD14 (sCD14) exists in human serum, and higher amounts of it are found in tuberculosis. A polymorphism on CD14 gene promoter was associated with increased sCD14 levels in some diseases. To evaluate whether this polymorphism associates with tuberculosis, its clinical forms, and increased sCD14, genotype/allele frequencies in tuberculosis patients were compared with the controls. Results confirmed increased levels of sCD14 in patients with tuberculosis, and those with miliary tuberculosis had the highest levels. sCD14 decreased to normal levels after anti-tuberculosis treatment. No association was found between the CD14 polymorphism and tuberculosis or sCD14 levels. Results suggest that sCD14 may be involved in anti-tuberculosis immune response, but its increase is a consequence of infection rather than a predisposed genetic trait. Measuring sCD14 in tuberculosis may help monitor anti-tuberculosis treatment.
结核分枝杆菌通过包括CD14在内的细胞表面分子与单核细胞-巨噬细胞相互作用。人血清中存在可溶性CD14（sCD14），在结核病患者中其含量更高。CD14基因启动子上的多态性在某些疾病中与sCD14水平升高有关。为了评估这种多态性是否与结核病、其临床类型以及sCD14升高相关，将结核病患者的基因型/等位基因频率与对照组进行了比较。结果证实结核病患者的sCD14水平升高，粟粒性结核病患者的sCD14水平最高。抗结核治疗后sCD14降至正常水平。未发现CD14多态性与结核病或sCD14水平之间存在关联。结果表明，sCD14可能参与抗结核免疫反应，但其升高是感染的结果而非遗传易感性特征。检测结核病患者的sCD14可能有助于监测抗结核治疗。
