Kabesch M, Hasemann K, Schickinger V, Tzotcheva I, Bohnert A, Carr D, Baldini M, Hackstein H, Leupold W, Weiland S K, Martinez F D, Mutius E, Bein G
University Children's Hospital, Ludwig Maximilian's University Munich, München, Germany.
Allergy. 2004 May;59(5):520-5. doi: 10.1111/j.1398-9995.2004.00439.x.
A polymorphism in the promoter region of the CD14 gene, C-159T, has been shown to be associated with increased levels of soluble CD14 (sCD14) and decreased serum immunoglobulin E (IgE) and the expression of a more severe atopic phenotype in previous studies.
To test if these associations are consistently found in different populations and different age groups, we genotyped 2048 children of different age groups as well as 888 adults from different regions of Germany for the CD14 C-159T polymorphism.
While an association between this promoter polymorphism and levels of sCD14 could be confirmed in our study population (CC: 1017 ng/ml vs TT: 1370 ng/ml, P = 0.03), no association between CD14 C-159T genotypes and IgE levels or the prevalence of atopic diseases was seen.
The lack of association between CD14 genotypes and IgE as well as atopic outcomes in this large German study population seems to indicate that CD14 genotypes may not directly be involved in the development of allergies during childhood.
在先前的研究中，CD14基因启动子区域的多态性C-159T已被证明与可溶性CD14（sCD14）水平升高、血清免疫球蛋白E（IgE）降低以及更严重的特应性表型表达有关。
为了测试这些关联是否在不同人群和不同年龄组中一致存在，我们对来自德国不同地区的2048名不同年龄组的儿童以及888名成年人进行了CD14 C-159T多态性基因分型。
虽然在我们的研究人群中可以确认这种启动子多态性与sCD14水平之间存在关联（CC：1017 ng/ml vs TT：1370 ng/ml，P = 0.03），但未观察到CD14 C-159T基因型与IgE水平或特应性疾病患病率之间存在关联。
在这个庞大的德国研究人群中，CD14基因型与IgE以及特应性结局之间缺乏关联，这似乎表明CD14基因型可能并不直接参与儿童期过敏的发生发展。
