Zamboni Dario S
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo SP 04023-062, Brazil.
Infect Immun. 2004 Apr;72(4):2395-9. doi: 10.1128/IAI.72.4.2395-2399.2004.
Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetii phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.
与来自C57BL/6、C57BL/10、B10.A、C3H/HePas和瑞士小鼠的巨噬细胞相比,A/J和BALB/c小鼠的巨噬细胞对贝氏柯克斯体II期感染更敏感。具有抗性的巨噬细胞有效地控制了大型复制液泡(LRV)的形成,这导致了细菌在培养物中的增殖受限。然而,与成纤维细胞相比,所有巨噬细胞都控制了LRV内的细菌增殖。