小鼠巨噬细胞体外对伯纳特立克次体感染天然抗性的遗传控制：来自限制菌株的巨噬细胞控制吞噬泡成熟。
Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: macrophages from restrictive strains control parasitophorous vacuole maturation.
作者信息
Zamboni Dario S
机构信息
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo SP 04023-062, Brazil.
出版信息
Infect Immun. 2004 Apr;72(4):2395-9. doi: 10.1128/IAI.72.4.2395-2399.2004.
Abstract
Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetii phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.
摘要
与来自C57BL/6、C57BL/10、B10.A、C3H/HePas和瑞士小鼠的巨噬细胞相比，A/J和BALB/c小鼠的巨噬细胞对贝氏柯克斯体II期感染更敏感。具有抗性的巨噬细胞有效地控制了大型复制液泡（LRV）的形成，这导致了细菌在培养物中的增殖受限。然而，与成纤维细胞相比，所有巨噬细胞都控制了LRV内的细菌增殖。
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