Wang Xiang-dong, Han De-min, Zhou Bing, Wei Yong-xiang, Bai Wen-zhong, Liu Zhong-yan, Ju Shu-ying
Beijing Tongren Center of Otorhinolaryngology Head-Neck Surgery, Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Dec;38(6):448-50.
To elucidate the mechanism of bone marrow response regulated by interleukin-5 (IL-5) in the model of allergic rhinitis.
Twenty SD rats were randomly divided into allergic rhinitis (AR) group and control group. The leucocytes in the smears of bone marrow and peripheral blood were counted, and the expression of IL-5 was detected by immunohistochemistry.
The ratio of eosinophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of basophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of eosinophils to white cells in peripheral blood smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of IL-5 positive cells to white cells in bone marrow smears of AR group was significantly higher than that of control group (P < 0.05). The ratio of IL-5 positive cells to white cells was significantly positively correlated with the ratio of eosinophils to white cells in bone marrow smears of AR group (R = 0.85, P < 0.01).
IL-5 regulates the proliferation and differentiation of eosinophils in bone marrow.
