Thomson Nicholas, Sebaihia Mohammed, Cerdeño-Tárraga Ana, Bentley Stephen, Crossman Lisa, Parkhill Julian
Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Nat Rev Microbiol. 2003 Oct;1(1):11-2. doi: 10.1038/nrmicro734.
With the number of published microbial genomes now in excess of 100, any new genome that is sequenced is likely to have a close relative available for comparison. Indeed, it is increasingly difficult to perform any genomic analysis that is not comparative. This should, however, not be seen as a drawback; it is often the case that a large amount of information can be drawn from these comparisons, especially between closely related organisms. Several genome sequences published recently indicate the value of comparisons at the genomic level.
目前已发表的微生物基因组数量超过了100个,因此新测序的任何基因组都可能有亲缘关系密切的基因组可供比较。事实上,不进行比较的基因组分析越来越困难。然而,这不应被视为一个缺点;通常可以从这些比较中获取大量信息,尤其是在亲缘关系密切的生物体之间。最近发表的一些基因组序列表明了基因组水平比较的价值。