Keller Martin, Zengler Karsten
Diversa Corporation, 4955 Directors Place, San Diego, California 92121, USA.
Nat Rev Microbiol. 2004 Feb;2(2):141-50. doi: 10.1038/nrmicro819.
Even though significant advances have been made in understanding microbial diversity, most microorganisms are still only characterized by 'molecular fingerprints' and have resisted cultivation. Many different approaches have been developed to overcome the problems associated with cultivation of microorganisms because one obvious benefit would be the opportunity to investigate the previously inaccessible resources that these microorganisms potentially harbour.
尽管在理解微生物多样性方面已经取得了重大进展，但大多数微生物仍然仅通过“分子指纹”来表征，并且难以培养。已经开发了许多不同的方法来克服与微生物培养相关的问题，因为一个明显的好处是有机会研究这些微生物可能蕴藏的以前无法获取的资源。
