桦木酸与氨基酸的酰胺及缀合物的合成与抗病毒活性

[Synthesis and antiviral activity of amides and conjugates of betulonic acid with amino acids].

作者信息

Flekhter O B, Boreko E I, Tret'iakova E V, Pavlova N I, Baltina L A, Nikolaeva S N, Savinova O V, Eremin V F, Galin F Z, Tolstikov G A

机构信息

Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054 Russia.

出版信息

Bioorg Khim. 2004 Jan-Feb;30(1):89-98. doi: 10.1023/b:rubi.0000015778.77887.f1.

DOI:10.1023/b:rubi.0000015778.77887.f1

PMID:15040309

Abstract

Betulonic acid amides with aliphatic and heterocyclic amines and with L-amino acids were synthesized by the acid chloride method. Betulonic acid amide and L-methionine derivatives of betulonic acid and its 3-oxime effectively inhibit the influenza A virus. Betulonic acid octadecylamide is active against the herpes simplex type 1 virus. The conjugate of betulonic acid 3-oxime with L-methionine is also active toward HIV-1. The tested compounds mainly show no activity toward the ECHO6 virus, which is devoid of a coat. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.

摘要

通过酰氯法合成了桦木酸与脂肪族和杂环胺以及与L-氨基酸形成的酰胺。桦木酸酰胺以及桦木酸及其3-肟的L-甲硫氨酸衍生物能有效抑制甲型流感病毒。桦木酸十八烷基酰胺对单纯疱疹病毒1型具有活性。桦木酸3-肟与L-甲硫氨酸的共轭物对HIV-1也有活性。所测试的化合物对无衣壳的艾柯病毒6型主要无活性。该论文的英文版本：《俄罗斯生物有机化学杂志》，2004年，第30卷，第1期；另见http://www.maik.ru 。