James Christopher W, Steinhaus Mary C, Szabo Susan, Dressier Robert M
HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899-1668, USA.
Pharmacotherapy. 2004 Mar;24(3):415-8. doi: 10.1592/phco.24.4.415.33182.
Tenofovir is a nucleotide reverse transcriptase inhibitor for treatment of human immunodeficiency virus (HIV) infection. Several cases of renal failure associated with tenofovir therapy recently have been reported. A 54-year-old man with HIV experienced decreasing renal function and Fanconi's syndrome secondary to tenofovir therapy. His condition gradually improved after discontinuation of the drug. The available medical literature for reported cases of tenofovir-related nephrotoxicity indicates that this complication is apparently rare. However, our case report and literature review underscore the importance of monitoring renal function when treating patients with any nucleotide reverse transcriptase inhibitor.
替诺福韦是一种用于治疗人类免疫缺陷病毒（HIV）感染的核苷酸逆转录酶抑制剂。最近有几例与替诺福韦治疗相关的肾衰竭病例报告。一名54岁的HIV男性患者因替诺福韦治疗出现肾功能下降和范科尼综合征。停药后他的病情逐渐好转。关于替诺福韦相关肾毒性报告病例的现有医学文献表明，这种并发症显然很少见。然而，我们的病例报告和文献综述强调了在使用任何核苷酸逆转录酶抑制剂治疗患者时监测肾功能的重要性。
