Malik Amyn, Abraham Paul, Malik Nadia
Department of Internal Medicine, University of Minnesota, 516 Delaware Street, MMC 194, PWB 14-110, Minneapolis, MN 55108, USA.
J Infect. 2005 Aug;51(2):E61-5. doi: 10.1016/j.jinf.2004.08.031.
Tenofovir disoproxil fumarate, a prodrug of tenofovir, is a potent nucleotide analogue reverse-transcriptase inhibitor with activity against human immunodeficiency virus (HIV). Although initially thought to be relatively safe with regards to nephrotoxic effects compared to its class drugs-adefovir and cidofovir, several cases of acute renal failure and proximal tubule dysfunction have been described in the last few months. We report another patient who developed Fanconi syndrome while on tenofovir. Her condition improved on discontinuation of the drug. We also review the literature of all patients who have developed Fanconi syndrome on tenofovir.
富马酸替诺福韦二吡呋酯是替诺福韦的前体药物，是一种有效的核苷酸类似物逆转录酶抑制剂，对人类免疫缺陷病毒（HIV）具有活性。尽管最初认为与同类药物阿德福韦和西多福韦相比，其肾毒性作用相对安全，但在过去几个月里，已有几例急性肾衰竭和近端肾小管功能障碍的病例被报道。我们报告了另一例在服用替诺福韦期间发生范科尼综合征的患者。停药后她的病情有所改善。我们还回顾了所有在服用替诺福韦后发生范科尼综合征的患者的文献。
