Wolf Christian, Lerebours Rachel
Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
Org Lett. 2004 Apr 1;6(7):1147-50. doi: 10.1021/ol049851s.
A palladium-phosphinous acid-catalyzed and NaOH-promoted coupling method using arylsiloxanes and aryl halides in water has been developed. The POPd1-catalyzed reaction between aryl chlorides or bromides and arylsiloxanes is compatible with various functional groups and affords biaryls in up to 99% yield. This cross-coupling reaction does not require additives such as surfactants or organic cosolvents and proceeds under air, which greatly facilitates operation and catalyst handling.
已开发出一种在水中使用芳基硅氧烷和芳基卤化物的钯-次膦酸催化及氢氧化钠促进的偶联方法。POPd1催化的芳基氯化物或溴化物与芳基硅氧烷之间的反应与各种官能团兼容，可提供高达99%产率的联芳基化合物。这种交叉偶联反应不需要表面活性剂或有机共溶剂等添加剂，并且在空气中即可进行，这极大地便于了操作和催化剂处理。
