钯-次膦酸催化的水中Sonogashira交叉偶联反应
Palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water.
作者信息
Wolf Christian, Lerebours Rachel
机构信息
Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
出版信息
Org Biomol Chem. 2004 Aug 7;2(15):2161-4. doi: 10.1039/b407773c. Epub 2004 Jun 30.
DOI:10.1039/b407773c
PMID:15280947
Abstract
A palladium--phosphinous acid-catalyzed Sonogashira cross-coupling reaction that proceeds in water under air atmosphere in the absence of organic co-solvents has been developed. Disubstituted alkynes have been prepared in up to 91% yield by POPd-catalyzed coupling of various aryl halides including chlorides in the presence of tetrabutylammonium bromide and pyrrolidine or NaOH.
摘要
已开发出一种钯-亚膦酸催化的Sonogashira交叉偶联反应，该反应在空气气氛下于水中进行，无需有机共溶剂。在四丁基溴化铵和吡咯烷或氢氧化钠存在下，通过钯催化各种芳基卤化物（包括氯化物）的偶联反应，已制备出产率高达91%的二取代炔烃。
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