Saini Jagjit S, Saroha Vandana, Singh P, Sukhija Jaspreet S, Jain Arun K
Advanced Eye Center, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Clin Exp Optom. 2004 Mar;87(2):97-101. doi: 10.1111/j.1444-0938.2004.tb03155.x.
The purpose of this study was to assess the demographic variables, age at diagnosis, keratometry and slitlamp signs in keratoconus.
Thirty-one patients with 61 keratoconic eyes were selected provided they met one of two criteria: 1. They had an irregular corneal surface, Vogt's striae, Fleischer's ring or apical sub-epithelial corneal scarring characteristic of keratoconus; 2. Corneal topography revealed an average simulated keratometry of more than 45.2 D, central corneal power higher than 47.2 D or infero-superior asymmetry greater than 1.4 D. The main outcome measures were demographic variables, age at diagnosis, disease severity on keratometry and biomicroscopic signs.
The patients' mean age at presentation was 20.2 +/- 6.4 years. Based on average keratometry values, 67.2 per cent of eyes had severe and 32.8 per cent had moderate keratoconus. Eyes with severe keratoconus presented at a younger average age (18.8 +/- 5.35 years) than moderate keratoconus (23.69 +/- 8.07 years). Thirty-eight eyes (92.5 per cent) with severe and 13 eyes (65 per cent) with moderate keratoconus demonstrated biomicroscopic signs of keratoconus. Twenty eyes (32.7 per cent) demonstrated apical sub-epithelial cornea scarring and 95 per cent of these eyes had severe keratoconus.
The majority of keratoconic eyes in Asian-Indian patients demonstrate the severe stage of the disease by the second decade.
本研究旨在评估圆锥角膜患者的人口统计学变量、诊断时的年龄、角膜曲率测量值和裂隙灯检查体征。
选取31例患者的61只圆锥角膜眼,入选标准为符合以下两条标准之一:1. 具有圆锥角膜特征性的不规则角膜表面、Vogt条纹、Fleischer环或角膜上皮下瘢痕;2. 角膜地形图显示平均模拟角膜曲率超过45.2 D、中央角膜屈光力高于47.2 D或上下径线不对称大于1.4 D。主要观察指标为人口统计学变量、诊断时的年龄、角膜曲率测量的疾病严重程度和生物显微镜检查体征。
患者就诊时的平均年龄为20.2±6.4岁。根据平均角膜曲率值,67.2%的眼睛为重度圆锥角膜,32.8%为中度圆锥角膜。重度圆锥角膜眼的平均就诊年龄(18.8±5.35岁)低于中度圆锥角膜眼(23.69±8.07岁)。38只(92.5%)重度圆锥角膜眼和13只(65%)中度圆锥角膜眼有圆锥角膜的生物显微镜检查体征。20只(32.7%)眼睛有角膜上皮下瘢痕,其中95%为重度圆锥角膜。
亚洲印度裔患者的大多数圆锥角膜眼在第二个十年时处于疾病的严重阶段。