Bozza Silvia, Montagnoli Claudia, Gaziano Roberta, Rossi Giordano, Nkwanyuo Gabriel, Bellocchio Silvia, Romani Luigina
Department of Experimental Medicine and Biochemical Sciences, Medical School, University of Perugia, 06122 Perugia, Italy.
Vaccine. 2004 Feb 17;22(7):857-64. doi: 10.1016/j.vaccine.2003.11.031.
Efficient responses to the different forms of fungi require different mechanisms of immunity. Dendritic cells (DCs) are uniquely able to decode the fungus-associated information and translate it in qualitatively different T helper (Th) immune responses, in vitro and in vivo. DCs sense fungi in a morphotype-specific manner, through the engagement of distinct recognition receptors ultimately affecting cytokine production and costimulation. Adoptive transfer of different types of DCs activates protective and non-protective Th cells as well as regulatory T cells and affects the outcome of the infections. DCs transfected with fungal RNA also restore antifungal resistance in hematopoietic transplantation. Thus, the remarkable functional plasticity of DCs in response to fungi can be exploited for the deliberate targeting of cells and pathways of cell-mediated immunity in response to fungal vaccines.
对不同形式真菌的有效反应需要不同的免疫机制。树突状细胞（DCs）具有独特的能力，能够解码与真菌相关的信息，并在体外和体内将其转化为性质不同的辅助性T细胞（Th）免疫反应。DCs通过不同识别受体的结合，以形态型特异性方式感知真菌，最终影响细胞因子的产生和共刺激。不同类型DCs的过继转移可激活保护性和非保护性Th细胞以及调节性T细胞，并影响感染的结果。用真菌RNA转染的DCs还可恢复造血移植中的抗真菌抗性。因此，DCs对真菌反应的显著功能可塑性可用于针对真菌疫苗，有意靶向细胞介导免疫的细胞和途径。
