树突状细胞在抗真菌免疫和疫苗设计中的作用。
Dendritic cells in antifungal immunity and vaccine design.
机构信息
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
出版信息
Cell Host Microbe. 2012 May 17;11(5):436-46. doi: 10.1016/j.chom.2012.04.005.
Abstract
Life-threatening fungal infections have increased in recent years while treatment options remain limited. The development of vaccines against fungal pathogens represents a key advance sorely needed to combat the increasing fungal disease threat. Dendritic cells (DC) are uniquely able to shape antifungal immunity by initiating and modulating naive T cell responses. Targeting DC may allow for the generation of potent vaccines against fungal pathogens. In the context of antifungal vaccine design, we describe the characteristics of the varied DC subsets, how DC recognize fungi, their function in immunity against fungal pathogens, and how DC can be targeted in order to create new antifungal vaccines. Ongoing studies continue to highlight the critical role of DC in antifungal immunity and will help guide DC-based vaccine strategies.
摘要
近年来，危及生命的真菌感染病例有所增加，而治疗选择仍然有限。针对真菌病原体开发疫苗是对抗不断增加的真菌疾病威胁的关键进展，非常有必要。树突状细胞 (DC) 通过启动和调节初始 T 细胞反应，具有独特的塑造抗真菌免疫的能力。靶向 DC 可能有助于针对真菌病原体生成有效的疫苗。在抗真菌疫苗设计的背景下，我们描述了不同 DC 亚群的特征、DC 识别真菌的方式、它们在对抗真菌病原体的免疫中的功能，以及如何靶向 DC 以创建新的抗真菌疫苗。正在进行的研究继续强调 DC 在抗真菌免疫中的关键作用，并将有助于指导基于 DC 的疫苗策略。
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