Joste Nancy E, Racz Mark I, Montgomery Karen Dyer, Haines Skip, Pitcher J David
Department of Pathology and Cytogenetics Laboratory, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Cancer Genet Cytogenet. 2004 Apr 1;150(1):73-7. doi: 10.1016/j.cancergencyto.2003.08.013.
Cellular schwannomas are uncommon tumors of Schwann cells that can rarely have a plexiform architecture. Cellular schwannomas can be confused with low-grade malignant peripheral nerve sheath tumors (MPNST) but have been noted to have a benign clinical course. There are few published cytogenetic analyses of cellular schwannomas and, to our knowledge, there are no reports of the plexiform variant of cellular schwannoma to date. Cellular schwannomas are reported to have cytogenetic changes similar to those seen in benign schwannomas with near-diploid karyotypes having simple numerical changes often involving chromosomes 22, 7, and the sex chromosomes. MPNST are markedly different, with extensive genetic heterogeneity and complex karyotypes. We report clonal numerical changes in a cellular schwannoma with plexiform architecture: 47,XY,+17 and 48,XY,+17,+18. These findings add to the karyotypic spectrum of peripheral nerve sheath tumors.
细胞性神经鞘瘤是一种罕见的施万细胞肿瘤，很少具有丛状结构。细胞性神经鞘瘤可能会与低级别恶性外周神经鞘膜瘤（MPNST）相混淆，但已注意到其临床病程为良性。关于细胞性神经鞘瘤的细胞遗传学分析报道较少，据我们所知，迄今为止尚无细胞性神经鞘瘤丛状变体的报告。据报道，细胞性神经鞘瘤的细胞遗传学变化与良性神经鞘瘤相似，近二倍体核型通常有简单的数目改变，常涉及22号、7号染色体和性染色体。MPNST则明显不同，具有广泛的遗传异质性和复杂的核型。我们报告了一例具有丛状结构的细胞性神经鞘瘤的克隆性数目改变：47,XY,+17和48,XY,+17,+18。这些发现增加了外周神经鞘膜瘤的核型谱。
