Manor Esther, Tetro Sarit, Noyhous Monica, Kachko Palina, Bodner Lipa
Genetic Institute, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O. Box 151 Beer-Sheva 84101, Israel.
Cancer Genet Cytogenet. 2009 Sep;193(2):116-8. doi: 10.1016/j.cancergencyto.2009.04.022.
Intraosseous schwannoma is rare, and most commonly occurs in the mandible. Benign classic schwannomas commonly carry normal karyotypes admixed with aberrant near-diploid karyotypes with a few simple clonal chromosome changes, mainly numerical. No consistent chromosomal aberrations have been observed so far. It is unclear whether the chromosomal abnormalities are affected by the anatomic site of the tumor; however, we know of no cytogenetic reports on schwannoma in the oral area. This novel report of cytogenetic analysis of intraosseous schwannoma represents the fifth report on a new balanced translocation in schwannoma in general. We identified clonal t(2;13) in an intraosseous schwannoma of the mandible. The significance of t(2;13) in diagnosis or prognosis is not yet clear, and should be further examined by karyotyping of more schwannoma cases.
骨内神经鞘瘤较为罕见，最常见于下颌骨。良性经典神经鞘瘤通常具有正常核型，并混有异常的近二倍体核型，伴有一些简单的克隆性染色体改变，主要是数目改变。迄今为止，尚未观察到一致的染色体畸变。尚不清楚染色体异常是否受肿瘤解剖部位的影响；然而，我们尚未见到关于口腔区域神经鞘瘤的细胞遗传学报告。这份关于骨内神经鞘瘤细胞遗传学分析的新报告是关于神经鞘瘤新的平衡易位的第五份报告。我们在一例下颌骨骨内神经鞘瘤中鉴定出克隆性t(2;13)。t(2;13)在诊断或预后中的意义尚不清楚，应通过对更多神经鞘瘤病例进行核型分析进一步研究。
