Ramael M, Colebunders R, Colpaert C, Goeman J, Schrijvers D, Lachenal M, Vandenbruaene M, Blot K, Van Marck E
Department of Pathology, University Hospital Antwerp, Belgium.
Int J STD AIDS. 1992 Jul-Aug;3(4):251-4. doi: 10.1177/095646249200300404.
The prevalence of hairy leukoplakia was determined among 176 symptomatic HIV seropositive patients seen at the outpatient department of the Institute of Tropical Medicine in Antwerp, Belgium. Moreover, systematic tongue biopsies were performed during postmortem examination of 21 patients with AIDS, 100 HIV seronegative immunocompromised patients with haematologic or other malignancies and 100 HIV seronegative non-immunocompromised patients who died at the University Hospital Antwerp. Hairy leukoplakia was observed in 52 (29.5%) of the outpatients, but only in one (5%) of the AIDS patients in the postmortem study (P = 0.03). An explanation for this difference may be that significantly more AIDS patients who died had received either acyclovir or ganciclovir during the 3 months prior to the postmortem examination than the HIV seropositive outpatients during the 3 months prior to examination. Hairy leukoplakia occurred more often in Caucasian homosexual men with HIV infection (38%) than among heterosexual Africans with HIV infection (17%) (P = 0.06). Hairy leukoplakia was observed in none of the HIV seronegative patients.
在比利时安特卫普热带医学研究所门诊部就诊的176名有症状的HIV血清阳性患者中，确定了毛状白斑的患病率。此外，在对21例艾滋病患者、100例患有血液系统或其他恶性肿瘤的HIV血清阴性免疫功能低下患者以及100例在安特卫普大学医院死亡的HIV血清阴性非免疫功能低下患者进行尸检时，进行了系统性舌活检。在门诊患者中，52例（29.5%）观察到毛状白斑，但在尸检研究中，仅1例（5%）艾滋病患者观察到毛状白斑（P = 0.03）。这种差异的一个解释可能是，在尸检前3个月内接受阿昔洛韦或更昔洛韦治疗的死亡艾滋病患者明显多于检查前3个月内的HIV血清阳性门诊患者。HIV感染的白人同性恋男性中毛状白斑的发生率（38%）高于HIV感染的非洲异性恋者（17%）（P = 0.06）。在HIV血清阴性患者中未观察到毛状白斑。
