Ouyang Wei, He Guo-rong, Liu Jin-hua
Department of Nuclear Medicine, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Mar;24(3):337-8.
To investigate the value of (99m)Tc-N-NOET(NOET) myocardial perfusion imaging during exercise in the diagnosis of coronary artery disease (CAD), and the relationship between exercise NOET lung/heart ratio and left ventricular diastolic function.
Exercise-delayed NOET myocardial perfusion imaging was performed in 49 patients undergoing coronary angiography, among whom 29 had coronary stenosis>or=50% and 20 normal coronary artery.
The sensitivity and specificity of exercise NOET myocardial perfusion imaging were 86.2% and 95.0%, respectively, in the detection of CAD. The NOET lung/heart ratio of CAD patients with multiple branch involvement (0.76+/-0.13) was significantly higher than those of patients with single branch lesion (0.62+/-0.06) and with normal coronary artery (0.58+/-0.13, F=18.04, P=0.002- 0.001). When the lung/heart ratio was over 0.70, the sensitivity and specificity of the imaging for detecting the presence of multiple branch involvement were 93.5% and 83.3%, respectively. NOET lung/heart ratio showed a significant correlation with E/A ratio (r=-0.771, P<0.000 1).
Exercise NOET lung/heart ratios has diagnostic values for multiple branch lesions and left ventricular diastolic function abnormalities in patients with CAD.
探讨运动负荷下99m锝-N-乙氧烟酰胺（NOET）心肌灌注显像在冠心病（CAD）诊断中的价值，以及运动负荷下NOET肺/心比值与左心室舒张功能的关系。
对49例行冠状动脉造影的患者进行运动负荷延迟NOET心肌灌注显像，其中29例冠状动脉狭窄≥50%，20例冠状动脉正常。
运动负荷NOET心肌灌注显像检测CAD的敏感性和特异性分别为86.2%和95.0%。多支病变CAD患者的NOET肺/心比值（0.76±0.13）显著高于单支病变患者（0.62±0.06）和冠状动脉正常患者（0.58±0.13，F=18.04，P=0.002 - 0.001）。当肺/心比值>0.70时，该显像检测多支病变的敏感性和特异性分别为93.5%和83.3%。NOET肺/心比值与E/A比值呈显著相关（r=-0.771，P<0.000 1）。
运动负荷下NOET肺/心比值对CAD患者多支病变及左心室舒张功能异常具有诊断价值。
