Fagret D, Marie P Y, Brunotte F, Giganti M, Le Guludec D, Bertrand A, Wolf J E, Piffanelli A, Chossat F, Bekhechi D
Service de Médecine Nucléaire, CHU de Nancy-Brabois, France.
J Nucl Med. 1995 Jun;36(6):936-43.
We compared TcN-NOET [bis(N-ethoxy, N-ethyl dithiocarbamato)nitrido 99mTc] and 201Tl images to estimate the utility of this compound in the detection of coronary artery disease (CAD).
Twenty-five patients undergoing cardiac catheterization had stress-redistribution-reinjection 201Tl SPECT imaging, stress-delayed (2, 4 and 6 hr postinjection) and rest-delayed (4 hr postinjection) TcN-NOET SPECT imaging.
Nineteen patients had coronary stenosis > or = 50% and six were normal. Stress TcN-NOET and 201Tl imaging were concordant for the presence of CAD in 22/25 patients (88%, kappa = 0.76 +/- 0.20). The overall sensitivity of TcN-NOET SPECT imaging was 74% (14/19 patients) and 68% (13/19 patients) for 201Tl SPECT imaging. The specificity was 100% (6/6 patients) for both techniques. The overall agreement of TcN-NOET and 201Tl for the presence of disease in individual coronary arteries was 96% (72/75 arteries, kappa = 0.92 +/- 0.16). Segmental analysis of stress images showed a concordance in 211/225 segments (94%, kappa = 0.82 +/- 0.09). Comparison of the 4-hr images showed a concordance between 201Tl and TcN-NOET in 21/23 patients. Following TcN-NOET injection at rest, seven patients had a defect on the initial images, which had normalized 4 hr postinjection in four patients (57%).
Perfusion imaging with TcN-NOET and 201Tl gives comparable diagnostic information in patients undergoing exercise testing for assessment of CAD. Because of the normalization of myocardial activity 4 hr after injection in some patients, we conclude that TcN-NOET is a potential technetium compound equivalent to 201Tl.
我们比较了TcN-NOET[双（N-乙氧基，N-乙基二硫代氨基甲酰基）氮99m锝]和201铊图像，以评估该化合物在检测冠状动脉疾病（CAD）中的效用。
25例接受心脏导管检查的患者进行了静息-再分布-再注射201铊单光子发射计算机断层显像（SPECT）成像、负荷延迟（注射后2、4和6小时）及静息延迟（注射后4小时）TcN-NOET SPECT成像。
19例患者冠状动脉狭窄≥50%，6例正常。负荷TcN-NOET和201铊成像在22/25例患者（88%，kappa=0.76±0.20）中对CAD的存在情况一致。TcN-NOET SPECT成像的总体敏感性为74%（14/19例患者），201铊SPECT成像为68%（13/19例患者）。两种技术的特异性均为100%（6/6例患者）。TcN-NOET和201铊对各冠状动脉疾病存在情况的总体一致性为96%（72/75支动脉，kappa=0.92±0.16）。负荷图像的节段分析显示211/225个节段一致（94%，kappa=0.82±0.09）。4小时图像的比较显示21/23例患者中201铊和TcN-NOET一致。静息注射TcN-NOET后，7例患者初始图像有缺损，其中4例（57%）在注射后4小时恢复正常。
在接受运动试验以评估CAD的患者中，TcN-NOET和201铊灌注成像提供了可比的诊断信息。由于部分患者注射后4小时心肌活性恢复正常，我们得出结论，TcN-NOET是一种等同于201铊的潜在锝化合物。
