Zeeman Gerda G, Fleckenstein James L, Twickler Diane M, Cunningham F Gary
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA.
Am J Obstet Gynecol. 2004 Mar;190(3):714-20. doi: 10.1016/j.ajog.2003.09.015.
This study was undertaken to characterize the neuroimaging findings of cerebral edema associated with eclamptic seizures by use of diffusion-weighted magnetic resonance imaging (MRI).
During the 3-year period ending March 2002, 27 nulliparous women with eclampsia were evaluated with diffusion-weighted MRI and apparent diffusion coefficient mapping. Those with findings of restricted diffusion suggestive of cytotoxic edema underwent neuroimaging again 6 weeks post partum.
All but 2 of these 27 women (93%) had reversible vasogenic edema. Six were also found to have areas of cytotoxic edema consistent with cerebral infarction. Five of these 6 women had persistent imaging findings of infarction when studied post partum, however, without clinical neurologic deficits.
The spectrum of cerebral lesions in eclampsia as seen with MRI varies from initially reversible areas of vasogenic edema that may progress to cytotoxic edema and infarction in up to a fourth of women.
本研究旨在通过使用扩散加权磁共振成像（MRI）来描述与子痫发作相关的脑水肿的神经影像学表现。
在截至2002年3月的3年期间，对27例初产妇子痫患者进行了扩散加权MRI和表观扩散系数成像评估。那些具有提示细胞毒性水肿的扩散受限表现的患者在产后6周再次接受神经影像学检查。
这27名女性中除2人外（93%）均有可逆性血管源性水肿。6人还被发现有与脑梗死一致的细胞毒性水肿区域。然而，这6名女性中有5人在产后检查时仍有梗死的影像学表现，但无临床神经功能缺损。
MRI所见子痫患者脑损伤谱从最初可逆的血管源性水肿区域到多达四分之一的女性可能进展为细胞毒性水肿和梗死不等。
