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Threonine is the best substrate for D-lactate formation in octopus tentacle.

作者信息

Akagi S, Ohmori S

机构信息

Kurashiki Central Hospital, Pharmaceutical Center, Miwa, Kurashiki, Japan.

出版信息

Amino Acids. 2004 Mar;26(2):169-74. doi: 10.1007/s00726-003-0043-7. Epub 2003 Oct 17.

DOI:10.1007/s00726-003-0043-7
PMID:15042447
Abstract

Carbon sources for D-lactate and enzyme activities related to D-lactate formation were investigated using cell-free homogenates of Octopus vulgaris tentacle tissue. The results are as follows: a) The best precursor for D-lactate formation was threonine and second best precursors were glycine and fructose-1,6-bisphosphate. Threonine and glycine served as precursors only in presence of glutathione. b) Both amino acids were precursors for methylglyoxal from which D-lactate was synthesized. Alanine, cysteine and serine were not precursors. We present a metabolic map for D-lactate formation in octopus in order to explain these experimental results.

摘要

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