Lorenzo Bermejo Justo, Rawal Rajesh, Hemminki Kari
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Cancer. 2004 Apr 1;100(7):1507-14. doi: 10.1002/cncr.20138.
Population-based data on the familial association of specific histologic types of ovarian malignancy with other malignancies are limited. Such data may help to elucidate etiologic differences among histologic types of ovarian malignancy.
The nationwide Swedish Family-Cancer Database, which includes 10.3 million individuals and 20,974 ovarian carcinomas, was used to calculate standardized incidence ratios and 95% confidence intervals for age- and histology-specific ovarian malignancies in women whose parents or siblings were affected with malignancies at the most common disease sites.
Ovarian malignancy was found to be associated with ovarian, laryngeal, breast, endometrial, liver, and colon carcinoma, as well as myeloma; epithelial ovarian malignancy was found to be associated with ovarian, endometrial, and skin malignancies and with melanoma and myeloma; papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and endometrioid carcinoma was found to be associated with endometrial, ovarian, and prostate malignancies and with melanoma. For younger women (ages 40-45 years) whose mothers were affected with endometrial malignancies, the risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma.
Specific types of ovarian malignancy may be associated with specific familial disease sites, with such associations depending on age at diagnosis; the strength of the observed associations varied according to histology. Associations were found between endometrioid carcinoma and endometrial malignancy and between serous carcinoma and Hodgkin disease.
关于卵巢恶性肿瘤特定组织学类型与其他恶性肿瘤家族关联的基于人群的数据有限。此类数据可能有助于阐明卵巢恶性肿瘤组织学类型之间的病因差异。
使用瑞典全国性家庭癌症数据库，该数据库包含1030万人和20974例卵巢癌，用于计算父母或兄弟姐妹在最常见疾病部位患恶性肿瘤的女性中，特定年龄和组织学类型的卵巢恶性肿瘤的标准化发病率比及95%置信区间。
发现卵巢恶性肿瘤与卵巢癌、喉癌、乳腺癌、子宫内膜癌、肝癌、结肠癌以及骨髓瘤有关；上皮性卵巢恶性肿瘤与卵巢癌、子宫内膜癌、皮肤恶性肿瘤、黑色素瘤和骨髓瘤有关；乳头状浆液性囊腺癌与卵巢癌、皮肤恶性肿瘤和骨髓瘤有关；子宫内膜样癌与子宫内膜癌、卵巢癌、前列腺癌以及黑色素瘤有关。对于母亲患子宫内膜恶性肿瘤的年轻女性（40 - 45岁），发生子宫内膜样癌的风险略高于发生乳头状浆液性囊腺癌的风险。
特定类型的卵巢恶性肿瘤可能与特定的家族性疾病部位有关，这种关联取决于诊断时的年龄；观察到的关联强度因组织学类型而异。发现子宫内膜样癌与子宫内膜恶性肿瘤之间以及浆液性癌与霍奇金病之间存在关联。
