Anderson Jeffrey P, Ross Julie A, Folsom Aaron R
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA.
Cancer. 2004 Apr 1;100(7):1515-21. doi: 10.1002/cncr.20146.
Reports on the relation between anthropometric variables (height, weight) and physical activity with ovarian cancer have been inconclusive. The objective of the current study was to extend investigation of potential associations in the Iowa Women's Health Study cohort.
The relation between self-reported anthropometric variables and incident ovarian cancer was studied in a prospective cohort of women ages 55-69 years who were followed for 15 years. Two hundred twenty-three incident cases of epithelial ovarian cancer were identified by linkage to a cancer registry.
No association was found overall between ovarian cancer and height, but a positive association was observed for serous ovarian cancers (relative risk [RR], 1.86 for highest quartile vs. lowest quartile; 95% confidence interval [95% CI], 1.06-3.29). Although current body mass index (BMI) was not associated with ovarian cancer, a BMI > or =30 kg/m2 at age 18 years appeared to be associated positively with ovarian cancer (multivariate-adjusted RR, 1.83 for BMI > or =30 kg/m2 vs. BMI <25 kg/m2; 95% CI, 0.90-3.72), and this association was stronger after exclusion of the first 2 years of follow-up (RR, 2.15; 95% CI, 1.05-4.40). In a multivariate analysis, waist-to-hip ratio was associated with ovarian cancer (RR, 1.59 for highest quartile vs. lowest quartile; 95% CI, 1.05-2.40), but a linear dose response was not found. An index that combined the frequency and intensity of leisure-time physical activity was associated positively with ovarian cancer incidence (multivariate-adjusted RR, 1.42 for high activity vs. low activity; 95% CI, 1.03-1.97). This association was particularly strong for frequency of vigorous physical activity (multivariate-adjusted RR, 2.38 for >4 times per week vs. rarely/never; 95% CI, 1.29-4.38).
Anthropometric variables were not major risk factors for ovarian cancer in the cohort studied; however, high BMI in early adulthood and frequent and vigorous physical activity may increase the risk of ovarian cancer among postmenopausal women.
关于人体测量学变量（身高、体重）与体育活动和卵巢癌之间关系的报告尚无定论。本研究的目的是在爱荷华州女性健康研究队列中进一步调查潜在关联。
在一个年龄为55 - 69岁的前瞻性女性队列中，研究自我报告的人体测量学变量与卵巢癌发病之间的关系，该队列随访了15年。通过与癌症登记处的数据链接，确定了223例上皮性卵巢癌发病病例。
总体上未发现卵巢癌与身高之间存在关联，但浆液性卵巢癌存在正相关（最高四分位数与最低四分位数相比，相对风险[RR]为1.86；95%置信区间[95%CI]为1.06 - 3.29）。虽然当前体重指数（BMI）与卵巢癌无关，但18岁时BMI≥30 kg/m²似乎与卵巢癌呈正相关（多变量调整RR，BMI≥30 kg/m²与BMI<25 kg/m²相比为1.83；95%CI为0.90 - 3.72），且在排除随访的前两年后这种关联更强（RR为2.15；95%CI为1.05 - 4.40）。在多变量分析中，腰臀比与卵巢癌有关（最高四分位数与最低四分位数相比，RR为1.59；95%CI为1.05 - 2.40），但未发现线性剂量反应关系。一个综合了休闲时间体育活动频率和强度的指数与卵巢癌发病率呈正相关（多变量调整RR，高活动量与低活动量相比为1.42；95%CI为1.03 - 1.97）。这种关联在剧烈体育活动频率方面尤为明显（多变量调整RR，每周>4次与很少/从不相比为2.38；95%CI为1.29 - 4.38）。
在所研究的队列中，人体测量学变量不是卵巢癌的主要危险因素；然而，成年早期的高BMI以及频繁且剧烈的体育活动可能会增加绝经后女性患卵巢癌的风险。
