Johnson J P
Institute for Immunology, Munich, Federal Republic of Germany.
Int J Clin Lab Res. 1992;22(2):69-72. doi: 10.1007/BF02591399.
In a variety of human malignancies, tumorigenesis and the development of metastatic disease are accompanied by changes in the expression of cell adhesion molecules. In carcinomas, normally expressed cell adhesion molecules are lost, or expressed in a functionally altered form, events which may help tumor cells to escape from contact-mediated controls and leave the primary tumor. The development of metastatic potential is, in a number of solid tumors, associated with the expression of new cell adhesion molecules by the tumor cells. These newly expressed cell adhesion molecules appear to mediate tumor cell interaction with leukocytes and endothelium, and may direct dissemination of the tumor cells throughout the body.
在多种人类恶性肿瘤中，肿瘤发生及转移性疾病的发展伴随着细胞黏附分子表达的变化。在 carcinomas 中，正常表达的细胞黏附分子丢失，或以功能改变的形式表达，这些事件可能有助于肿瘤细胞逃避接触介导的控制并离开原发性肿瘤。在许多实体瘤中，转移潜能的发展与肿瘤细胞表达新的细胞黏附分子有关。这些新表达的细胞黏附分子似乎介导肿瘤细胞与白细胞和内皮细胞的相互作用，并可能引导肿瘤细胞在全身扩散。 （注：carcinomas 一般译为“癌” ，这里保留英文是因为原文中可能是特定语境下的术语。）
