Levi M, Bronkhorst C, Noorduyn L A, Vreeken J
Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.
J Clin Pathol. 1994 Sep;47(9):858-9. doi: 10.1136/jcp.47.9.858.
The occurrence of unexplained, rapidly recurring occlusions of arteries and veins in a previously healthy young woman is described. Post mortem examination showed no macroscopic abnormalities but revealed microscopic metastatic adenocarcinoma with remarkable intravascular localisation of the malignant cells. Whereas highly sensitive markers for the existence of systemic activation of blood coagulation remained within the normal range, it is suggested that specific characteristics of the tumour cells may have been responsible for this particular clinical presentation.
本文描述了一名此前健康的年轻女性出现不明原因的、迅速复发的动静脉闭塞情况。尸检未发现宏观异常，但发现了微观转移性腺癌，恶性细胞在血管内有显著定位。尽管用于检测血液凝固系统激活的高敏标志物仍在正常范围内，但提示肿瘤细胞的特定特征可能是导致这种特殊临床表现的原因。
